学习和工作经历
2005.09-2009.07,天津大学,获学士学位
2010.09-2013.07,天津大学,获硕士学位
2013.09-2017.12,天津大学,获博士学位
2014.09-2018.01,布鲁塞尔自由大学,获博士学位
2018.07-2022.12,南开大学医学院,讲师
2022.12-至今,南开大学医学院,副研究员
无
研究方向
1.抗体与免疫
2.食品安全性检测
3.肠道肿瘤靶向与治疗
主持科研项目
1. 基于纳米抗体的Macadamia过敏原致敏机制研究和痕量检测, 国家自然科学基金青年项目, 2020.01-2022.12.
代表性论文与专利
长期从事驼源纳米抗体的研究与应用，研究方向包括食品安全性检测，抗体与免疫学研究及肠道肿瘤的靶向与治疗，主持国家自然科学基金一项，发表了多篇学术论文。
1. Zhang J, Shao Z, Hu Y, Liu B, Zhang Y, Wang S. Formation of a creatinine thermal degradation product and its role and participation in the radical pathway of forming the pyridine ring of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Food Chem, 2020, 312:126083.
2. Ning Zhao, Jing-Min Liu, Shuang Liu, Xue-Meng Ji, Huan Lv, Yao-Zhong Hu, Zhi-Hao Wang, Shi-Wen Lv, Chun-Yang Li and Shuo Wang. A novel universal nano-luciferase-involved reporter system for long-term probing food-borne probiotics and pathogenic bacteria in mice by in situ bioluminescence imaging. RSC Adv, 2020, 10: 13029-13036
3. Ma H, Zhang B, Hu Y, Wang J, Liu J, Qin R, Lv S, Wang S. Correlation Analysis of Intestinal Redox State with the Gut Microbiota Reveals the Positive Intervention of Tea Polyphenols on Hyperlipidemia in High Fat Diet Fed Mice. J Agric Food Chem, 2019, 67(26):7325-7335.
4. Cawez F, Duray E, Hu Y, Vandenameele J, Romão E, Vincke C, Galleni M, Muyldermans S, Vandevenne M. Combinatorial design of a nanobody that specifically targets structured RNAs. Journal of Molecular Biology, 2018, 11: 1652-1670.
5. Hu Y, Romão E, Vertommen D, Vincke C, Morales-Yánez F, Gutiérrez C, Liu C, Muyldermans S. Generation of Nanobodies against SlyD and development of tools to eliminate this bacterial contaminant from recombinant proteins. Protein Expression and Purification, 2017, 137:64-76.
6. Hu Y, Liu C, Muyldermans S. Nanobody-based delivery systems for diagnosis and targeted tumor therapy. Frontiers in Immunology, 2017, 8:1442.
7. Romão E, Morales-Yánez F, Hu Y, Crauwels M, De Pauw P, Hassanzadeh GG, Devoogdt N, Ackaert C, Vincke C, Muyldermans S. Identification of useful nanobodies by phage display of immune single domain libraries derived from camelid heavy chain antibodies. Current Pharmaceutical Design, 2016, 22:6500-6518.
8. Li M, Fan X, Liu J, Hu Y, Huang H. Selection by phage display of nanobodies directed against hypoxia inducible factor-1alpha (HIF-1alpha). Applied Biochemistry and Biotechnology, 2015, 62:738-745.
9. Huang H, Song C, Yang Z, Dong Y, Hu Y, Gao F. Identification of the replication origins from Cyanothece ATCC 51142 and their interactions with the DnaA protein: from in silico to in vitro studies. Frontiers in Microbiology, 2015, 6:1370.
10. Fan X, Hu Y, Huang H. Nanobodies: Novel biomedical vehicles in targeting tumor. Journal of Chemical and Pharmaceutical Research, 2014, 6:458-462.
11. Hu Y, Liu J, Huang H. Recent agents targeting HIF-1alpha for cancer therapy. Journal of Cellular Biochemistry, 2013, 114:498-509.
荣誉和奖励
2013年, 教育部, 研究生国家奖学金
2017年, 布鲁塞尔自由大学, 博士奖学金
联系方式
通讯地址：天津市津南区同砚路38号 南开大学医学院334室 300350
电子邮件：yzhu@nankai.edu.cn