学习和工作经历
2009.09-2013.06，东北农业大学食品学院，获学士学位
2013.09-2019.06，中国农业大学食品科学与营养工程学院，获博士学位
2017.11-2018.11，哈佛大学医学院，国家公派联合培养
2019.07-2024.03，中国农业大学，博士后
2024.04-至今，南开大学医学院，副教授
学术与社会任职
研究方向
1. 食品中生物/化学危害物毒性效应与机制研究
2. 食品安全评价体系中新型生物模型的构建及应用研究
主持科研项目
1.构建适配体-肾脏ECM复合型水凝胶辅助的肾脏类器官及其在赭曲霉毒素A毒理学评价中的应用, 国家自然科学基金青年项, 2021.01-2023.12。
2.利用DNA水凝胶实现类器官3D细胞培养支架的组装及其在黄曲霉毒素毒理评价中的应用, 博士后创新人才支持计划，2019.07-2021.06。
代表性论文与专利
累计发表SCI论文33篇，其中第一作者12篇（一区4篇，二区 7篇，三区 1篇）；授权国家发明专利4项。
1. Zhu L#, Yu H#, Xu W, et al. Aptamer functionalized nucleic acid nano drug for targeted synergistic therapy for colon cancer. Journal of Nanobiotechnology. 2023 Jun 7;21(1):182.
2. Zhu L*, Yuhan J, Yu H, et al. Decellularized Extracellular Matrix for Remodeling Bioengineering Organoid’s Microenvironment. Small. 2023 Mar 16:e2207752.
3. Zhu L, Zhong H, Cheng N, et al. A Peroxidase-like single-atom catalyst based on atomically dispersed Fe-N5 active sites in graphene nanosheets for effective killing of human lung adenocarcinoma cells. Nano Research. 2022.
4. Yuhan#, Zhu L#, Zhu L, et al. Cell-specific aptamers in therapeutic applications: a review of current progress. Journal of Controlled Release. 2022 May 4; 346:405-420.
5. Asakiya C#, Zhu L#, Yuhan J，et al. Current Progress of miRNA-derivative Nucleotide Drugs: Modifications, Delivery Systems, and Applications. Expert Opinion on Drug Delivery, 2022 Apr;19(4):435-450.
6. Zhu L, Yuhan J, Huang K, et al. Multidimensional analysis of the epigenetic alterations in toxicities induced by mycotoxins. Food and Chemical Toxicology, 2021 Jul; 153:112251.
7. Zhu L, Wang H, Yuhan J, et al. Exosomes mediated the delivery of ochratoxin A-induced cytotoxicity in HEK293 cells. Toxicology, 2021 Sep; 461:152926.
8. Zhu L#, Huang C#, Yang X, et al. Proteomics reveals the alleviation of zinc towards aflatoxin B1-induced cytotoxicity in human hepatocyes (HepG2 cells). Ecotoxicology and Environmental Safety, 2020, 7(198):110596.
9. Zhu L, Zhang B, Dai Y, et al. A review: epigenetic mechanism in ochratoxin a toxicity studies, Toxins, 2017, 9(4):113.
10. Zhu L, Yu T, Qi X, et al. Limited link between oxidative stress and ochratoxin A-Induced renal injury in an acute toxicity rat model. Toxins, 2016, 8(12):373.
11. Zhu L, Gao J, Huang K, et al. miR-34a screened by miRNA profiling negatively regulates Wnt/β-catenin signaling pathway in Aflatoxin B1 induced hepatotoxicity. Scientific Reports. 2015 Nov 16; 5:16732.
12. Zhu L, Yu T, Qi X, et al. miR-122 plays an important role in ochratoxin A-induced hepatocyte apoptosis in vitro and in vivo. Toxicology Research. 2015 Oct 8;5(1):160-167.
荣誉和奖励
无
联系方式
通讯地址：天津市津南区同砚路38号 南开大学医学院335室 300350