2007.09-2011.07, 辽宁大学, 获学士学位
2011.09-2014.07, 大连理工大学, 获硕士学位
2014.09-2018.07, 大连理工大学, 获博士学位
2018.09-2023.12, 南开大学医学院, 讲师
2023.12-至今, 南开大学医学院, 副教授
学术与社会任职
1.中华医学会, 会员
研究方向
1.天然药物和食品活性成分预防糖尿病和IBD的机制
2.膳食营养与肠道菌群的相互作用
3.多酚的肠道代谢
主持科研项目
1.多种食物致敏原精准快速检测技术标准及配套产品研制, 国家重点研发计划SQ2019YFC160018“食物过敏标识的风险评估技术研究”子课题, 2019-2022.
2.小米膳食干预肠道健康的机制研究, 中央高校基本科研业务费, 2019-2020.
代表性论文与专利
长期从事食品功能因子调节健康的肠道机制和肠道代谢研究，近五年发表SCI论文13篇，申请发明专利7项
代表性论文：
1. Zhang B, Dong Y*, Yu N, Sun Y, Xing Y, Yang F, Yu X, Sun W, Sun J, Li X, Xiu Z. Intestinal Metabolism of Baicalein after Oral Administration in Mice: Pharmacokinetics and Mechanisms. Journal of Functional Foods, 2019, 54:53-63.
2. Ding Q#, Zhang B#, Zheng W, Chen X; Zhang J, Yan R, Zhang T, Yu L, Dong Y*, Ma B*. Liupao tea extract alleviates diabetes mellitus and modulates gut microbiota in rats induced by streptozotocin and high-fat, high-sugar diet, Biomedicine & Pharmacotherapy, 2019, 118: 0-UNSP 109262.
3. Zhang B, Sun W, Yu N, Sun J, Yu X, Li X, Xing Y, Yan D, Ding Q, Xiu Z, Ma B, Yu L, Dong Y*. Anti-Diabetic Effect of Baicalein is Associated with the Modulation of Gut Microbiota in Streptozotocin and High-Fat-Diet Induced Diabetic Rats. Journal of Functional Foods, 2018, 46:256-267.
4. Zhang B, Li X, Sun W, Xing Y, Xiu Z, Zhuang C, Dong Y*. Dietary Flavonoids and Acarbose Synergistically Inhibit α-Glucosidase and Lower Postprandial Blood Glucose. Journal of Agricultural and Food Chemistry, 2017, 65:8319−8330.
5. Zhang B, Sang Y, Sun W, Yu H, Ma B, Xiu Z, Dong Y*. Combination of Flavonoids from Oroxylum indicum Seed Extracts and Acarbose Improves the Inhibition of Postprandial Blood Glucose: In Vivo and In Vitro Study. Biomedicine & Pharmacotherapy, 2017, 91:890-898.
6. Zhang B, Xing Y, Wen C, Yu X, Sun W, Xiu Z, Dong Y*. Pentacyclic Triterpenes as α-Glucosidase and α-Amylase Inhibitors: Structure-activity Relationships and the Synergism with Acarbose. Bioorganic & Medicinal Chemistry Letters, 2017, 27:5065-5070.
7. Ma H, Zhang B, Hu Y, Wang J, Liu J, Qin R, Lv S, Wang S*. Correlation Analysis of Intestinal Redox State with the Gut Microbiota Reveals the Positive Intervention of Tea Polyphenols on Hyperlipidemia in High Fat Diet Fed Mice. Journal of Agricultural and Food Chemistry, 2019, 67(26).
8. Sun W, Zhang B, Yu X, Zhuang C, Li X, Sun J, Xing Y, Xiu Z, Dong Y*, Oroxin A from Oroxylum indicum prevents the progression from prediabetes to diabetes in streptozotocin and high-fat-diet induced mice, Phytomedicine, 2018, 38:24-34.
9. Sun W, Zhang B, Zheng H, Zhuang C, Li X, Lu X, Quan C, Dong Y*, Zheng Z*, Xiu Z, Trivaric Acid, a New Inhibitor of PTP1b with Potent Beneficial Effect on Diabetes. Life Sciences, 2016, 169:52-64.
10. Ding Q, Zheng W, Zhang B, Chen X, Zhang J, Pang X, Zhang Y, Jia D, Pei S, Dong Y, Ma B*. Comparison of hypoglycemic effects of ripened pu-erh tea and raw pu-erh tea in streptozotocin-induced diabetic rats. RSC Advances, 2019, 9(6):2967-2977.
11. Sun W, Sun J, Zhang B, Xing Y, Yu X, Li X, Xiu Z, Dong Y*, Baicalein Improves Insulin Resistance Via Regulating SOCS3 and Enhances the Effect of Acarbose on Diabetes Prevention. Journal of Functional Foods, 2017, 37:339-353.
12. Sun W, Sang Y, Zhang B, Yu X, Xu Q, Xiu Z, Yuesheng Dong*. Synergistic Effects of Acarbose and an Oroxylum indicum Seed Extract in Streptozotocin and High-Fat-Diet Induced Prediabetic Mice. Biomedicine & Pharmacotherapy, 2017, 87:160-70.
13. Sun W, Zhuang C, Li X, Zhang B, Lu X, Zheng Z, Dong Y*. Varic Acid Analogues from Fungus as PTP1B Inhibitors: Biological Evaluation and Structure–activity Relationships. Bioorganic & Medicinal Chemistry Letters, 2017, 27:3382–3385.
发明专利：
1. 董悦生、张博崴、孙文龙、桑元斌、于晓霞、修志龙，一种具有α-糖苷酶抑制活性的药物组合物及其应用，专利号：ZL201510081001.8，授权日：2018.07.13
2. 董悦生，张博崴，文琛，孙文龙，余娜，修志龙. 具有α-淀粉酶协同抑制活性的组合物，申请号：201710466865.0
2. 董悦生、孙文龙、张博崴、李夏、修志龙，预防或治疗前驱糖尿病的药物和药物组合物，中国发明专利，专利号：ZL201710619663.5，授权日：2019.11.19
3. 董悦生、孙文龙、张博崴、李夏、修志龙，一种预防或治疗脂肪肝的药物及其应用，中国发明专利，申请号：ZL201710625595.3，授权日：2020.02.18
4. 董悦生、孙文龙、张博崴、桑元斌、于晓霞、徐亲民、修志龙，一种改善高脂高糖饮食并发症的药物组合物及其应用，专利号：ZL201510079721.0，授权日：2017.12.05
5. 董悦生、桑元斌、张博崴、徐亲民、修志龙，一种预防糖尿病药物组合物及其应用，专利号：ZL201210159072.1，授权日：2013.06.19
6. 董悦生、桑元斌、张博崴、徐亲民、修志龙，一种降糖药物组合物及其应用, 中国发明专利，专利号：ZL201210158501.3，授权日：2013.06.19
荣誉和奖励
2017年, 教育部, 博士研究生国家奖学金
2018年, 教育部, 辽宁省普通高等学校优秀毕业生
联系方式
通讯地址：天津市津南区同砚路38号 南开大学医学院334室 300350
电子邮件：bwzhang@nankai.edu.cn